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NIKOOTEC CLINICAL TRIALS

The interest generated by our programme of country-wide awareness raising among health care practitioners and specialists has led to the undertaking of numerous independent, high quality clinical trials carried out on the range of products that we exclusively represent. 

The clinical trials below represent an independent body of scientific work by leading specialists. Nearly all are double or triple-blind, randomised, placebo controlled trials.

We are proud that our activity has led to a huge increase in interest and multi-fold expansion in research output in our regions, in some very important fields of knowledge. 

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Synbiotic Supplementation in Non-alcoholic Fatty Liver Disease: a Randomised, Double-Blind, Placebo-Controlled Pilot Study

 

Eslamparast T, Poustchi H, Zamani F, Sharafkhah M, Malekzadeh R, Hekmatdoost A

 

Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Science

 

American Journal of Clinical Nutrition, January 2014

 

 

2. International Journal of preventive m

Effect of a Probiotic and Metformin on Liver Aminotransferases in Non-Alcoholic Steatohepatitis: a Double Blind Randomised Clinical Trial

 

Shavakhi A, Minakari M, Firouzian H, Assali R, Hekmatdoost A, Ferns G

 

Department of Gastroenterology and Liver Disease, Isfahan University of Medical Science; School of Medicine, Institute for Science and Technology in Medicine, Faculty of Health, University of Keele, Staffordshire

 

International Journal of Preventive Medicine, December 2012

 

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Effects of Synbiotic Supplementation on Insulin Resistance in Subjects with Metabolic Syndrome: a Randomised, Double-Blind Placebo-Controlled Pilot Study

 

Eslamparast, T, Zamani, F, Hekmatdoost, A, Sharafkhah, M, Eghtesad, S, Malekzadeh, R, Poustchi, H

 

Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Science

 

British Journal of Nutrition, May 2014

5. International Journal of Food science

The Effects of Synbiotic Supplementation on some Cardio-Metabolic Risk Factors in Overweight and Obese Children: a Randomised Triple-Masked Controlled Trial

 

Kelishadi R, Safavi M, Farajian S, Mirlohi, Hashemipour M

 

Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Esfahan University of Medical Sciences; Department of Pediatrics, Child Growth and Development Research Center, Isfahan University of Medical Sciences

International Journal of Food Sciences and Nutrition, March 2013

 

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A Randomized Triple-Masked Controlled Trial on the Effects of Synbiotics on Inflammation Markers in Overweight Children

 

Kelishadi R, Farajian S, Safavi M, Mirlohi M, Hashemipour M

Department of Pediatrics, Child Growth and Development Research Center, Isfahan University of Medical Sciences; School of Nutrition and Food Sciences, Isfahan University of Medical Sciences

Jornal de Pediatria, March 2014

16. Journal of Paediatrics and CHild Hea

Synbiotic in the Management of Infantile Colic: a Randomised Controlled Trial

Kianifar H, Ahanchian H, Grover Z, Jafari S, Noorbakhsh Z, Khakshour A, Sedaghat M, Kiani M.

Pediatric Gastroenterology, Mashhad University of Medical Sciences, Mashad, Khorasan; Queensland Children's Medical Research Institute, Royal Children's Hospital, Brisbane, Queensland, Australia

Journal of Pediatrics and Child Health, Australia, October 2014

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The Effect of Probiotic plus Prebiotic Supplementation on the Tolerance and Efficacy of Helicobacter Pylori Eradication Quadruple Therapy: a Randomized Prospective Double Blind Controlled Trial

 

Shafaghi A, Pourkazemi A, Khosravani M, Fakhrie Asl S, Amir Maafi A, Atrkar Roshan Z, Abaspour J

Member of Gastrointestinal and Liver Diseases Research Center (GLDRC) and Gastroenterology  Department, Guilan University of Medical Sciences, Rasht; Infectious Disease Department, Guilan University of Medical Sciences, Rasht.

Middle East Journal of Digestive Diseases, June 2016

Journal of Research in Medical Sciences.

Multistrain Probiotic and Lactulose in the Treatment of Minimal Hepatic Encephalopathy

 

Shavakhi A, Hashemi H, Tabesh E, Derakhshan Z, Farzamnia S, Meshkinfar S, Shavakhi S,

Minakari M, Gholamrezaei A

Department of Internal Medicine, Medical Students’ Research Center, Esfahan University of Medical Sciences, Esfahan

 

Journal of Research in Medical Sciences, August 2014

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A Randomized Clinical Trial with a Multistrain Probiotic Product in Acute Watery Diarrhea in Iranian Children

Allahverdi B, Ghorbani Vaghei A, Miri M, Foroughi S, Delfan B

Children's Medical Center Hospital, Tehran University of Medical Sciences; Lorestan University of Medical Sciences

Govaresh Journal, Scientific Journal of the Association of Gastroenterology and Hepatology, Supplement, Autumn 2014

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Synbiotic Preparation in Men Suffering from Functional Constipation: a Randomised Double-Blind Placebo Controlled Trial

 

Fateh R, Iravani, S, Frootan M, Rasouli M, Saadat S

School of Medicine, Tehran University of Medical Science

Swiss Medical Weekly, July 2011

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The Effect of Probiotics on Childhood Constipation:  A Randomized Controlled Double Blind Clinical Trial

Sadeghzadeh M, Rabieefar A, Khoshnevisasl P, Mousavinasab N, Eftekhari K

Department of Pediatrics, Zanjan Metabolic Disease Research Center, Zanjan University of Medical Sciences, Zanjan

Department of Epidemiology, Zanjan University of Medical Sciences, Zanjan

International Journal of Pediatrics, April 2014

17. Journal of Allergy & Clinical Immuno

A New Synbiotic Can Increase Weight Gain in Infants with Cow's Milk Allergy: a Randomised-Controlled Trial

Kianifar H, Ahanchian H, Jafari S, Farid R

Department of Pediatric Allergy and Immunology, Department of Pediatrics, Mashad University of Medical Sciences, Mashhad

Journal of Allergy Clinical Immunology, vol131, 2013

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Effects of Synbiotic Supplementation on Total Antioxidant Capacity of Human Breast milk

Nikniaz L, Mahdavi R, Ostadrahimi A, Hejazi MA, Vatankhah AM.

Nutrition Research Center, School of Public Health & Nutrition, Tabriz University of Medical Sciences, Tabriz

Breastfeeding Medicine, April 2013

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Effects of Synbiotic Supplementation on Breast Milk Levels of IgA TGF-ß1, and TGF-ß2

Nikniaz L, Ostadrahimi A, Mahdavi R, Hejazi MA, Salekdeh GH

Nutrition Research Center, School of Public Health & Nutrition, Tabriz University of Medical Sciences, Tabriz

Journal of Human Lactation, November 2013

5. International Journal of Food science

Effects of Synbiotic Supplementation on Lactating Mothers' Energy Intake and BMI, and Infants' Growth

Ostadrahimi A, Nikniaz L, Mahdavi R, Hejazi MA, Nikniaz Z.

Nutrition Research Center, School of Public Health & Nutrition, Tabriz University of Medical Sciences, Tabriz

International Journal of Food Science and Nutrition, September 2013

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Randomised Double Blind Placebo Control Trial on Effect of Probiotics on Fecal Calprotectin (a Marker of Bowel Inflammation) CF Patient in Children with Protexin

Fallahi G, Motamed F, Yousefi A, Shafieyoun A, Najafi M, Khodadad A, Farhmand F, Ahmadvand A, Rezaei N

Department of Pediatric Gastroenterology, School of Medicine, Tehran University of Medical Sciences, Tehran

The Turkish Journal of Pediatrics, September 2013

19. Qom University of Medical Sciences J

Effect of Probiotic Supplement on Immune Response in Male Athletes:  A Randomized Clinical Trail

Aghaee M, Khosravi N, Hanachi P, Kordi M R, Aghaee R.

Department of Physical Education, Qom University of Medical Sciences, Qom; Faculty of Physical Education & Sport Sciences, Alzahra University, Tehran; Department of Biochemistry, Faculty of Sciences, Alzahra University, Tehran

Qom University of Medical Sciences Journal, February 2013

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Comparison between Fluconazole with Oral Protexin Combination and Fluconazole in the Treatment of Vulvovaginal Candidiasis

Nouraei S, Amir Ali Akbari S, Jorjani M, Alavi Majd H, Afrakhteh M, Ghafoorian A, Tafazzoli Harandi H.

Faculty of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, International Branch, Tehran,

ISRN Obstetrics and Gynecology, December 2012

Journal of Womens Health, Issues, Care.p

Comparison of Metronidazole versus a Combination of Metronidazole plus Probiotics in the Treatment of Bacterial Vaginosis

Tafazzoli Harandi H, Amir Ali Akbari S, Afrakhteh M, Alavi Majd H, Nouraei S, Ashari Z, Jamilfar H

Department of Midwifery, Faculty of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran

Department of Obstetrics Gynecology, Faculty of Shahid Beheshti University of Medical Sciences, Tehran; Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran

Journal of Women’s Health, Issues and Care, May 2014

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The Effects of a Multispecies Probiotic Supplement on Inflammatory Markers and Episodic and Chronic Migraine Characteristics: A Randomized Double-blind Controlled Trial

 

Fahimeh Martami, Mansoureh Togha, Maryam Seifishahpar, Zeinab Ghorbani, Hossein Ansari, Tahereh Karimi and Soodeh Razeghi Jahromi

Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran

 

Headache Department, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran

 

School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran

The University of California, San Diego, CA, USA

Cephalalgia, January 2019

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